Ultimate Testosterone Boost

Promotes healthy testosterone production in men

NPN 80073228

The Ultimate line is about improving lives, one body at a time, by correcting and maintaining metabolism and hormone balance as well as providing stress and immune support. Effective nutrient supplementation can often be the missing piece to optimal health. Our supplements are carefully formulated to provide the Ultimate in abundant energy, metabolism, health, and longevity.

Benefits:

• Helps promote healthy testosterone production in men
• Ideal for men looking to support physical performance, energy levels, and vitality
• Helps improve athletic performance when combined with regular resistance training
• Helps increase resistance to stress/anxiety in people with a history of chronic stress
• Features essential nutrients for men’s health, including zinc, vitamin D3, and B vitamin

Research

Testosterone production begins to decline in men after the age of 30, and while reduced testosterone is often dismissed as part of the normal aging process, this decline in testosterone can affect energy, performance, muscle mass and fat distribution, hair growth, and even emotional and cognitive well-being. (1) Ensuring a good intake of essential nutrients needed for testosterone production can help support male reproductive health, energy metabolism, and hormone health in men, whatever their age.

Zinc is an essential nutrient for protein metabolism, healing, and sexual function. Zinc is also important for the regulation of testosterone levels, with research showing that in older men with marginal zinc deficiency, daily zinc supplementation for six months helps increase serum testosterone. (2) Zinc also non-competitively inhibits 5-alphareductase activity, decreasing the conversion of testosterone to its less desirable metabolite, dihydrotestosterone, which is linked to male pattern baldness and prostate enlargement. (3)

Vitamin D3 is an essential nutrient needed for a range of physiological processes, including supporting bone and immune health. In one study, vitamin D3 was found to increase testosterone levels by 30% in overweight men. (4)

Ashwagandha is a plant in the nightshade family, traditionally used in Ayurvedic medicine. Its active constituents include alkaloids (isopelletierine, anaferine), steroidal lactones (withanolides, withaferins), and saponins. (5) Ashwagandha has demonstrated antioxidant and adaptogenic effects, as well as immunomodulatory effects, and has been associated with an increase in testosterone levels in men. (6,7,8)

Testosterone Boost is formulated with KSM-66 that offers the highest concentration full-spectrum ashwagandha root extract available and is one of the best researched ashwagandha extracts on the market, having demonstrated benefits for stress, and enhancement of energy, endurance, and sexual function in men.

One eight-week, randomized, double-blind, placebo-controlled trial looked at the effects of ashwagandha on men aged 18–50 years old with little experience in resistance training. The 57 men were randomly assigned to receive either a placebo or 300 mg of KSM-66 ashwagandha twice daily and both groups underwent resistance training for eight weeks. The ashwagandha group had significantly greater increases in testosterone level and muscle size and strength after eight weeks, compared to placebo. The men taking ashwagandha also had significantly greater reduction of exercise-induced muscle damage and body fat percentage, compared to placebo. (8)

Piperine is the active alkaloid constituent of black pepper and has been seen to support digestive function and enhance the availability of nutrients including zinc and chromium, which are needed for testosterone production (9). Piperine also has antioxidant activity, helping to protect against systemic oxidative damage, and may even support normal levels of serotonin, an important “feel-good” neurotransmitter. (9,10,11)

Chromium is an important mineral for blood glucose regulation, and low levels of zinc and chromium have been associated with low testosterone in people with type 2 diabetes. (12) Vitamins B6 and B12 are important for energy metabolism, nerve function, and cardiovascular and cognitive function, and can be depleted by stress, poor diet, and certain medications. (13,14)

3,3’-diindolylmethane (DIM) is a bioactive metabolite found in cruciferous vegetables (such as broccoli) that seem to support normal processes of detoxification, including the proper elimination of hormone metabolites. (15)

Cordyceps has demonstrated antioxidant and immunomodulatory effects and appears to support testosterone levels and athletic performance in men engaged in endurance sports. (16,17)

Each vegetarian capsule contains:

Non-medicinal ingredients:

Vegetarian capsule (cellulose, purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.

Recommended adult dose: 1 capsule 2 times daily with food, a few hours before or after taking other medications, or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.

References

1. Van den Beld, A.W., de Jong, F.H., Grobbee, D.E., et al. (2000). Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab, 85(9), 3276-82.

2. Prasad, A.S., Mantzoros, C.S., Beck, F.W., et al. (1996). Zinc status and serum testosterone levels of healthy adults. Nutrition, 12(5), 344-8.

3. Leake, A., Chisholm, G. D., Habib, F. K. (1984). The effect of zinc on the 5-alpha-reduction of testosterone by the hyperplastic human prostate gland. J Steroid Biochem, 20(2), 651-5.

4. Pilz, S., Frisch, S., Koertke, H., et al. (2011). Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res, 43(3), 223-5.

5. Bhattacharya, S.K., Satyan, K.S., Ghosal, S. (1997). Antioxidant activity of glycowithanolides from Withania somnifera. Indian J Exp Biol, 35, 236-9.

6. Narinderpal, K., Junaid, N., Raman, B. (2013). A review on pharmacological profile of Withania somnifera (Ashwagandha). Research and Reviews: Journal of Botanical Sciences, 2(4), 6-14.

7. Upton, R., ed. (2000). Ashwagandha root (Withania somnifera): analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia, 1-25.

8. Wankhede, S., Langade, D., Joshi, K., et al. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr, 12(1), 43.

9. Srinivasan, K. (2007). Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr, 47(8), 735-48.

10.Meghwal, M., Goswami, T.K. (2013). Piper nigrum and piperine: an update. Phytother Res, 27(8), 1121-30.

11.Bahramsoltani, R., Farzaei, M.H., Farahani, et al. (2015). Phytochemical constituents as future antidepressants: a comprehensive review. Rev Neurosci, 26(6), 699- 719.

12.Ubajaka, C.F., Meludu, S.C., Dioka, C.E., et al. (2015). Evaluation of male sex hormones and trace elements in male type 2 diabetic patients attending Nnamdi Azikiwe University Teaching Hospital Diabetic Clinics. Niger J Med, 24(2), 162-8.

13.National Institutes of Health. Office of Dietary Supplements. Vitamin B6 Fact Sheet for Health Professionals. Accessed February 28, 2018. Retrieved from https://ods. od.nih.gov/factsheets/ VitaminB6-HealthProfessional/

14.National Institutes of Health. Office of Dietary Supplements. Vitamin B12 Fact Sheet for Health Professionals. Accessed February 28, 2018. Retrieved from https://ods. od.nih.gov/factsheets/ VitaminB12-HealthProfessional/

15.Gee, J.R., Saltzstein, D.R., Messing, et al. (2016). Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy. Eur J Cancer Prev, 25(4), 312-20.

16.Rossi, P., Buonocore, D., Altobelli, E., et al. (2014). Improving training condition assessment in endurance cyclists: effects of ganoderma lucidum and ophiocordyceps sinensis dietary supplementation. Evid Based Complement Alternat Med, 2014:979613.

17.Yue, K., Ye, M., Zhou, Z., et al. (2013). The genus cordyceps: a chemical and pharmacological review. J Pharm Pharmacol, 65(4), 474-93.